abstract：:Lithium is well established as a treatment of manic-depressive illness. As for the mechanism of action of lithium, it is proposed that lithium has effects on intracellular calcium ion (Ca2+) movement. But there are few reports in which the effects of lithium on intracellular Ca2+ movement are observed in the mammalian...

journal_title：Neurochemistry international

authors： Okamoto Y,Kagaya A,Motohashi N,Yamawaki S

更新日期：1995-03-01 00:00:00

abstract：:Many pharmacological and toxicological studies of centrally acting drugs are undertaken in animals at doses expressed in mg.kg-1, and the results extrapolated to the clinical dose in man. Safety margins based on such no or lowest effect levels may have little relevance since they do not take into account differences i...

journal_title：Neurochemistry international

authors： Campbell DB

更新日期：1995-02-01 00:00:00

abstract：:The dopaminergic projection from the substantia nigra to the neostriatum is vulnerable to several neurotoxins including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), amphetamine, and 5-hydroxydopamine. We have treated rats or mice with these agents and examined various regions of their brains with a combination...

journal_title：Neurochemistry international

authors： Linder JC,Young SJ,Groves PM

更新日期：1995-02-01 00:00:00

abstract：:Receptors for transmitters, as varied as those expressed by neurons, have been described on primary astrocyte cultures prepared from new-born rats and mice. A variety of functional effects and considerable cell-to-cell and regional heterogeneity have been observed for such receptors in vitro. The various systems avail...

journal_title：Neurochemistry international

authors： Kimelberg HK

更新日期：1995-01-01 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), an inducer of parkinsonism, causes degeneration of nigro-striatal dopaminergic neurons by producing its neurotoxic metabolite, 1-methyl-4-phenylpiridium ion (MPP+), by monoamine oxidase B in glial cells. We used PC12 (rat pheochromocytoma cell line) as a model cell ...

journal_title：Neurochemistry international

authors： Itano Y,Kitamura Y,Nomura Y

更新日期：1994-11-01 00:00:00

abstract：:In the present investigation we address the question of whether one of the responses to increased neuronal activity is a modification of the expression of the different subunits of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-selective glutamate receptors (GluR-1, GluR-2, GluR-3). Thus, we used two dif...

journal_title：Neurochemistry international

authors： Condorelli DF,Belluardo N,Mudò G,Dell'Albani P,Jiang X,Giuffrida-Stella AM

更新日期：1994-10-01 00:00:00

abstract：:The consequences of irreversibly-inhibiting D2 dopaminergic receptors on the expression of D1 and D2 dopamine receptor mRNAs and proenkephalin mRNA and on the levels of mu- and delta-opioid receptors in rat striatum were studied following single or repeated administration of the irreversibly-acting D2 dopamine recepto...

journal_title：Neurochemistry international

authors： Chen JF,Aloyo VJ,Qin ZH,Weiss B

更新日期：1994-10-01 00:00:00

abstract：:Differentiating granule cells develop survival requirements in vitro which can be met by treatment with high K+ or excitatory amino acids. Promotion of cell survival by N-methyl-D-aspartate (NMDA) or kainate has already been established and here we report that treatment of the cells with alpha-amino-3-hydroxy-5-methyl...

journal_title：Neurochemistry international

authors： Hack N,Balázs R

更新日期：1994-09-01 00:00:00

abstract：:The neuromodulator adenosine, has been shown to have the highest density of central uptake sites in the nucleus tractus solitarius in the dorsal brain stem. The nucleus tractus solitarius is involved in the central regulation of reflex cardiovascular activity suggesting that adenosine may also be involved in central c...

journal_title：Neurochemistry international

authors： Lawrence AJ,Castillo-Meléndez M,Jarrott B

更新日期：1994-09-01 00:00:00

abstract：:Brain cortex synaptoneurosomes actively incorporated [14C]arachidonic acid (AA) into lipids. Serotonin (5-HT), at a concentration range of 10 microM-1 mM, significantly stimulates the incorporation of AA mainly into phosphatidylinositol (PI) of brain cortex synaptoneurosomes. The stimulation rate of AA incorporation b...

journal_title：Neurochemistry international

authors： Strosznajder J,Samochocki M,Duran M

更新日期：1994-08-01 00:00:00

abstract：:In this paper, two different aspects of growth hormone neuroregulation during aging were considered. Twenty-month-old male rats had decreased growth hormone-releasing hormone mRNA levels and a slight reduction of somatostatin mRNA levels in the hypothalamus when compared to 8-month-old counterparts. Short-term adminis...

journal_title：Neurochemistry international

authors： De Gennaro Colonna V,Cella SG,Parenti M,Locatelli V,Cocchi D,Müller EE

更新日期：1994-07-01 00:00:00

abstract：:The effects of dithiothreitol (DTT) and, reduced (GSH) and oxidized (GSSG), glutathione on the release of [3H]GABA evoked by glutamate and its agonists were studied in rat hippocampal slices. DTT had no effect on the basal release of [3H]GABA but it enhanced and prolonged the glutamate agonist-evoked release. This eff...

journal_title：Neurochemistry international

authors： Janáky R,Varga V,Oja SS,Saransaari P

更新日期：1994-06-01 00:00:00

abstract：:The phenylglycines 3-hydroxyphenylglycine, 4-carboxy-3-hydroxy-phenylglycine (4C3HPG), 4-carboxyphenylglycine (4CPG) and alpha-methyl-4-carboxyphenylglycine (MCPG) were evaluated as putative selective antagonists of metabotropic glutamate receptors on single neurones of the ventrobasal thalamus of rats, with a view to...

journal_title：Neurochemistry international

authors： Salt TE,Eaton SA

更新日期：1994-05-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) levels and the activity of glutamate decarboxylase were measured in homogenates of rat brain cortical tissue, at different times after chronic intracortical infusion of GABA in vivo during 2, 6 or 24 h. Cortical electrical activity was also recorded. As previously described, about 1 h af...

journal_title：Neurochemistry international

authors： Salazar P,Montiel T,Brailowsky S,Tapia R

更新日期：1994-04-01 00:00:00

abstract：:The immunostains of GD3, c-pathway polysialogangliosides and gangliotetraosylgangliosides belonging to the a- and b-pathways were analyzed in embryo optic lobe cells. Cells were cultured in serum free media with, and without, bovine brain ganglioside mixture (largely gangliotetraosylgangliosides). Control cells differ...

journal_title：Neurochemistry international

authors： Cossy-Isasi S,Panzetta P

更新日期：1994-04-01 00:00:00

abstract：:Guanidinosuccinate (GSA) and methylguanidine (MG) are endogenous, convulsant guanidino compounds which have been shown to be greatly increased in uremic patients. In the present study, we have investigated the age-related differences in convulsive action and cerebral uptake of these compounds in juvenile mice of 7, 14...

journal_title：Neurochemistry international

authors： D'Hooge R,Pei YQ,Marescau B,De Deyn PP

更新日期：1994-03-01 00:00:00

abstract：:A pre-requisite to understanding the physiological mechanisms of action of melatonin is the identification of the target sites where the hormone acts. The radioligand 2-[125I]iodo-melatonin has been used extensively to localize binding sites in both the brain and peripheral tissues. In general these binding sites have...

journal_title：Neurochemistry international

authors： Morgan PJ,Barrett P,Howell HE,Helliwell R

更新日期：1994-02-01 00:00:00

abstract：:ATPase activities in CNS membranes were studied after administration of desipramine (DMI), a noradrenaline (NA) uptake inhibitor. In a previous paper we reported that Na+,K(+)-ATPase activity significantly increased 3 h after DMI administration (10 mg/kg) in hypothalamus and mesencephalus but not in cerebral cortex an...

journal_title：Neurochemistry international

authors： Viola MS,Rodríguez de Lores Arnaiz G,Enero MA

更新日期：1994-01-01 00:00:00

abstract：:Several endogenous brain substances which inhibit [3H]muscimol binding were isolated, and one of them has been purified to apparent homogeneity. The purification involved the extraction of brain tissue with water, followed by several steps of gel filtration column chromatography and high performance liquid chromatogra...

journal_title：Neurochemistry international

authors： Tang XW,Yarom M,Carlson RG,Vander Velde D,Huang PY,Lee YH,Seah EC,Deupree D,Wu JY

更新日期：1993-11-01 00:00:00

abstract：:Lipid peroxidation (LP) is a complex process which involves the formation of lipid free radicals and leads to oxidative damage. LP has also been implicated in several neurodegenerative diseases as well as aging. In the present study, we evaluated the effects of the induction of LP in vitro on muscarinic cholinergic (M...

journal_title：Neurochemistry international

authors： Ghosh C,Dick RM,Ali SF

更新日期：1993-11-01 00:00:00

abstract：:The vasoactive peptide, endothelin-1 (ET-1) has been implicated in the pathophysiology of various diseases. Recently, we have shown that human brain endothelial cells both secrete and express immunoreactive ET-1 high-affinity ETA receptors coupled to activation of phospholipase C (PLC). The present study demonstrates ...

journal_title：Neurochemistry international

authors： Stanimirovic DB,Bacic F,Uematsu S,Spatz M

更新日期：1993-10-01 00:00:00

abstract：:A purification procedure to obtain peroxisomes (microperoxisomes) from the brain of suckling rats is reported. A P2 fraction, (crude light mitochondria) frozen and thawed seven times, was subfractionated yielding a P4 fraction, 4-fold enriched in catalase activity with respect to the cytoplasmic extract S1. The P4 fra...

journal_title：Neurochemistry international

authors： Cimini AM,Moreno S,Giorgi M,Serafini B,Cerú MP

更新日期：1993-09-01 00:00:00

abstract：:Control of serotonin release and synthesis by amino acid neurotransmitters was investigated in rat rostral and caudal rhombencephalic raphe cells in primary cultures respectively. Endogenous amounts of taurine, glycine, GABA and glutamate were measured in both types of cultures. These amino acids were spontaneously re...

journal_title：Neurochemistry international

authors： Becquet D,Hery M,Francois-Bellan AM,Giraud P,Deprez P,Faudon M,Fache MP,Hery F

更新日期：1993-09-01 00:00:00

abstract：:Using a consistent, reproducible and reliable cortical focal ischemia in rat (permanent unilateral occlusion of the left middle cerebral artery & the ipsilateral common carotid artery [MCAo + CCAo] with a 1 h temporary occlusion of the contralateral CCA), the levels of four major membrane fatty acids (palmitic, C16:0;...

journal_title：Neurochemistry international

authors： Mahadik SP,Hungund BL,Gokhale VS,Ortiz A,Makar TK,Karpiak SE

更新日期：1993-08-01 00:00:00

abstract：:We demonstrated that genetically modified fibroblasts can be encapsulated into biocompatible, biodegradable spheres retaining their viability and capacity to continuously secrete nerve growth factor (NGF) for at least two months. Genetically engineered rat fibroblasts producing NGF were encapsulated in an alginate-pol...

journal_title：Neurochemistry international

authors： Maysinger D,Piccardo P,Filipovic-Grcic J,Cuello AC

更新日期：1993-08-01 00:00:00

abstract：:The effects of ageing on the turnover of dopamine, noradrenaline and serotonin in the lateral geniculate nucleus and the visual cortex were evaluated, using high performance liquid chromatography (HPLC) with electrochemical detection. Compared to adult animals, aged rats showed more changes in the visual cortex than i...

journal_title：Neurochemistry international

authors： Herrera AJ,Machado A,Cano J

更新日期：1993-06-01 00:00:00

abstract：:Two puromycin-sensitive aminopeptidase isozymes (PSA-I and PSA-II) were isolated from chicken brain cytosol by ammonium sulfate fractionation followed by column chromatography on Cellex D and AH-Sepharose 4B and separated on Bio-Gel HTP. Each was purified to homogeneity on Sephadex G-200, Arg-Tyr-AH-Sepharose, Bio-Gel...

journal_title：Neurochemistry international

authors： Hui KS,Saito M,Hui M,Saito M,Lajtha A,Yamamoto K,Osawa T

更新日期：1993-05-01 00:00:00

abstract：:Posttranslational processing of peptide-precursors is nowadays believed to play an important role in the functioning of neurons and endocrine cells. Both proenkephalins and chromogranins/secretogranins are considered as precursor molecules in these tissues, resulting in posttranslationally formed degradation products ...

journal_title：Neurochemistry international

authors： Dillen L,Miserez B,Claeys M,Aunis D,De Potter W

更新日期：1993-04-01 00:00:00

abstract：:In the central nervous system, choline is an essential precursor of choline-containing phospholipids in neurons and glial cells and of acetylcholine in cholinergic neurons. In order to study choline transport and metabolism in the brain, we developed a comprehensive methodical procedure for the analysis of choline and...

journal_title：Neurochemistry international

authors： Klein J,Gonzalez R,Köppen A,Löffelholz K

更新日期：1993-03-01 00:00:00

abstract：:In order to elucidate the effects of MPTP on enkephalinergic neurons, dopamine (DA), norepinephrine (NE), proenkephalin (PE) mRNA and met-enkephalin (ME) were measured in striatum, olfactory tubercle, and prefrontal cortex of C57/B16 mice 1 day-2 weeks following treatment with 96 mg/kg MPTP HCl (24 mg/kg i.p., twice/d...

journal_title：Neurochemistry international

authors： Mitsuo K,Cosi C,Harvey-White JD,Schwartz JP

更新日期：1993-02-01 00:00:00

abstract：:Diisopropyl phosphorofluoridate (DFP) produces Type I organophosphorus compound-induced delayed neurotoxicity (OPIDN) in adult female chickens. We have proposed that calcium/calmodulin protein kinase II (CaM kinase II) plays a role in the development of OPIDN by increasing the phosphorylation of cytoskeletal proteins....

journal_title：Neurochemistry international

authors： Abou-Donia MB,Viana ME,Gupta RP,Anderson JK

更新日期：1993-02-01 00:00:00

abstract：:Bindings of glutamate receptor agonists and related modulators were investigated in 10 discrete tissues from gerbil brain using a biochemical technique. There appeared considerable discrepancies, in respect of intrahippocampal profiles, from reported data by autoradiography on rat brain. In the gerbil, an almost equiv...

journal_title：Neurochemistry international

authors： Kataoka K,Mitani A,Andou Y,Enomoto R,Ogita K,Yoneda Y

更新日期：1993-01-01 00:00:00

abstract：:Primary cultures of cerebral cortical astrocytes and neurons, as well as neurons growing on top of the astrocytes (sandwich co-cultures), were incubated with 1-[13C]glucose or 2-[13C]acetate and in the presence or absence of the glutamine synthetase inhibitor methionine sulfoximine. [13C]NMR spectroscopy at 125 MHz wa...

journal_title：Neurochemistry international

authors： Sonnewald U,Westergaard N,Schousboe A,Svendsen JS,Unsgård G,Petersen SB

更新日期：1993-01-01 00:00:00

abstract：:Striatal quinolinic acid lesions have been used as a model for the pathology seen in Huntington's disease. Seven days following a unilateral injection of 100 nmol of quinolinic acid into the rat caudate-putamen (striatum), a large increase in the binding of [3H]WIN 35,428 to the lesioned caudate-putamen was seen when ...

journal_title：Neurochemistry international

authors： Gehlert DR,Schoepp DD

更新日期：1992-12-01 00:00:00

abstract：:Whereas carbachol, noradrenaline, serotonin and memantine stimulated inositol phosphates production and calcium mobilization in 3-5 day old rabbit retinal cultures, only carbachol and noradrenaline were effective when 25-30 day old cultures were used. The older retinal cultures contain only Müller cells which shows th...

journal_title：Neurochemistry international

authors： Osborne NN,Quack G

更新日期：1992-10-01 00:00:00

abstract：:The present studies were performed in order to examine the possible role of cyclic GMP-stimulated phosphodiesterase (cGMP-PDE) activity in the inhibitory action of the inflammatory peptide bradykinin on cyclic AMP (cAMP) accumulation in D384 cells. Bradykinin decreased the forskolin-stimulated cAMP accumulation in the...

journal_title：Neurochemistry international

authors： Altiok N,Fredholm BB

更新日期：1992-09-01 00:00:00

abstract：:Initial studies demonstrated the loss of lysine and simultaneous appearance of glucitollysine in intracellular proteins following incubation with sugar. For example, when a crude nervous tissue cytoskeletal preparation was incubated in 100 mM glucose for 10 days, > 60% of the lysine residues were modified. Over 20% of...

journal_title：Neurochemistry international

authors： Brown MR,Keith TJ,Knull HR

更新日期：1992-09-01 00:00:00

abstract：:Interactions between endothelin-1 (ET)-induced phosphoinositide (PI) hydrolysis and agents that increase Ca2+ influx (i.e. A23187 and ionomycin) or induce depolarization (i.e. KCl) were investigated using C6 glioma. A23187 dose-dependently potentiated ET (30 nM)- and ATP (100 microM)-induced [3H]inositol phosphate (IP...

journal_title：Neurochemistry international

authors： Lin WW,Chuang DM

更新日期：1992-09-01 00:00:00

abstract：:The effects of a cerebral anti-ischemic drug ifenprodil on the receptor ionophore complex of an N-methyl-D-aspartate (NMDA)-sensitive subclass of central excitatory amino acid receptors were examined using [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10- imine (MK-801) binding in rat brain synaptic memb...

journal_title：Neurochemistry international

authors： Ogita K,Ohkawara A,Suzuki T,Ohgaki T,Uchida S,Meguri H,Yoneda Y

更新日期：1992-07-01 00:00:00

abstract：:Sprague-Dawley rats exposed to uncontrollable shock can be separated by a subsequent shock escape test into two groups: a "helpless" (LH) group which demonstrates a deficit in escape behavior, and a "nonlearned helpless" (NLH) group which shows no escape deficit and acquires the escape response as readily as naive con...

journal_title：Neurochemistry international

authors： Edwards E,Kornrich W,van Houtten P,Henn FA

更新日期：1992-07-01 00:00:00